I connected a Wacom drawing tablet to my home computer many years ago. I used it with drawing programs on the computer rather than a conventional mouse. While it worked well, my next dilemma was the need to switch back and forth between the mouse and the drawing pen. To streamline the use of both devices, I did what made sense at the time. I started to use one of these left-handed; I chose to move the mouse.
Having about half a dozen computers between home and work, I changed all the mice to be left-handed. I reversed the function of the two mouse buttons and moved the mouse to the other side. I endured the first week with excruciating futility; by the end of the second week, I could accomplish most tasks without much struggle. However, this little activity taught me more than mere muscle memory, it gave me a new perspective on my biases.